Stem Cell Transplants Squashed HIV and Leukemia

Elsevier Global Medical News. 2009 Feb 11, S Boschert

Stem-cell transplantations in a patient with acute myeloid leukemia and HIV have kept the leukemia in remission and the HIV undetectable for 20 months without the use of antiretroviral therapies.The stem cells came from bone marrow in a human leukocyte antigen-compatible donor chosen because his cells lacked expression of chemokine receptor 5 (CCR5). Infection with HIV type 1 requires the presence of a CD4 receptor and either CCR5 or, less commonly, the CXC chemokine receptor (CXCR4). The case report,...

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