Mitotic Index, Tumor Size, and Location Predict GIST Relapse

Elsevier Global Medical News. 2010 Mar 1, K Wachter

ORLANDO (EGMN) - Mitotic index emerged as a leading predictor of relapse-free survival in a retrospective analysis of data and tumor tissue from a phase III study of more than 700 patients with localized primary gastrointestinal stromal tumors.On multivariate analysis, high mitotic rate (hazard ratio 11.3, P less than .0001), tumor size (HR 2.0, P less than .0001), and small bowel location (HR 1.7, P = .02) were all statistically significant, and should be considered in making therapy choices, Dr....

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