KRAS Mutation in Colorectal Cancer Rules Out Treatment Success With Cetuximab

Elsevier Global Medical News. 2008 Jun 2, ME Schneider

CHICAGO (EGMN) - Colorectal cancer patients whose tumors contain the wild-type KRAS gene responded better to treatment with cetuximab plus chemotherapy than did patients with tumor KRAS mutations, according to data presented during a June 1 plenary presentation at the annual meeting of the American Society of Clinical Oncology. More patients with wild-type KRAS tumors responded to cetuximab (Erbitux) plus the FOLFIRI (leucovorin, fluorouracil, and irinotecan) chemotherapy regimen (59%) than to FOLFIRI...

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