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Fostamatinib Active Against Diffuse Large B-Cell Lymphoma, CLL
Fostamatinib Active Against Diffuse Large B-Cell Lymphoma, CLL
JS MacNeil
20081119
2008 Dec 19
Elsevier Global Medical News
Fostamatinib Active Against Diffuse Large B-Cell Lymphoma, CLL
Elsevier Global Medical News. 2008 Dec 19, JS MacNeil
SAN FRANCISCO (EGMN) - Early clinical trials of a new targeted oral drug called fostamatinib disodium show it to be highly active in non-Hodgkin's lymphomas that exhibit what is being described as an addiction to B-cell receptor signalling.Fostamatinib (also known as R788) inhibits a protein called SYK (spleen tyrosine kinase) that regulates the B-cell receptor's ability to send a survival signal to cancer cells. It produced significant responses in patients with diffuse large B-cell lymphoma (DLBCL)...