Triple-negative Breast Cancer: Molecular Features, Pathogenesis, Treatment and Current Lines of Research
Triple-negative Breast Cancer
A Bosch, P Eroles, R Zaragoza, JR Viña, A Lluch
Yes
20100401
2010 May 1
Cancer Treat Rev
Triple-negative Breast Cancer: Molecular Features, Pathogenesis, Treatment and Current Lines of Research
Cancer Treat Rev. 2010 May 1;36(3):206-215, A Bosch, P Eroles, R Zaragoza, JR Viña, A Lluch
Abstract
Abstract
Breast cancer is a heterogeneous disease with different morphologies, molecular profiles, clinical behaviour and response to therapy. The triple negative is a particular type of breast cancer defined by absence of oestrogen and progesterone receptor expression as well as absence of ERBB2 amplification. It is characterized by its biological aggressiveness, worse prognosis and lack of a therapeutic target in contrast with hormonal receptor positive and ERBB2+ breast cancers. Given these characteristics,...
