Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment – An overview
Rui Amaral Mendes, João FC Carvalho, Isaac van der Waal
20100001
2010 Jan 1
Oral Oncol
Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment – An overview
Oral Oncol. 2010 Jan;46(1):19-24, Rui Amaral Mendes, João FC Carvalho, Isaac van der Waal
Abstract
Abstract
In the classification of Head and Neck Tumors, published in 2005 by the World Health Organization Classification, the odontogenic keratocyst has been reclassified as a benign intraosseous neoplasm, calling it “keratocystic odontogenic tumor” (KCOT).Significant differences on the molecular level between KCOT and other odontogenic cystic lesions suggest a different biological origin. Genetic and molecular research regarding odontogenic tumors, and KCOTs in particular, has led to an increasing amount...
