Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer
David J. Stewart
20100801
2010 Sept 1
Crit Rev Oncol Hematol
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer
Crit Rev Oncol Hematol. 2010 Sept;75(3):173-234, David J. Stewart
Abstract
Abstract
While chemotherapy provides useful palliation, advanced lung cancer remains incurable since those tumors that are initially sensitive to therapy rapidly develop acquired resistance. Resistance may arise from impaired drug delivery, extracellular factors, decreased drug uptake into tumor cells, increased drug efflux, drug inactivation by detoxifying factors, decreased drug activation or binding to target, altered target, increased damage repair, tolerance of damage, decreased proapoptotic factors,...
