Review Role of Topotecan in Gynaecological Cancers: Current Indications and Perspectives
Role of Topotecan in Gynecologic Cancers
D Lorusso, A Pietragalla, S Mainenti, V Masciullo, G Di Vagno, G Scambia
Yes
20100501
2010 Jun 1
Crit Rev Oncol Hematol
Review Role of Topotecan in Gynaecological Cancers: Current Indications and Perspectives
Crit Rev Oncol Hematol. 2010 Jun 1;74(3):163-174, D Lorusso, A Pietragalla, S Mainenti, V Masciullo, G Di Vagno, G Scambia
Abstract
Abstract
Background: Ovarian cancer is the fourth cause of death from gynaecological cancer and cervical cancer is the first in women <45 years old in developing countries. The aim of this article is to review the role of topotecan (Hycamtin®), a semi-synthetic alkaloid derivative of camptothecin, in ovarian and cervical cancer in monotherapy and in combination. Methods: This article reviews the mechanism of action, pharmacokinetics, toxicity and efficacy of topotecan. The paper also reports the principal...
