Preoperative radiochemotherapy for resectable localised oesophageal cancer: A controversial strategy
G. Crehange, F. Bonnetain, K. Peignaux, G. Truc, N. Blanchard, P. Rat, B. Chauffert, F. Ghiringhelli, P. Maingon
20100801
2010 Sept 1
Crit Rev Oncol Hematol
Preoperative radiochemotherapy for resectable localised oesophageal cancer: A controversial strategy
Crit Rev Oncol Hematol. 2010 Sept;75(3):235-242, G. Crehange, F. Bonnetain, K. Peignaux, G. Truc, N. Blanchard, P. Rat, B. Chauffert, F. Ghiringhelli, P. Maingon
Abstract
Abstract
Preoperative chemoradiation (P-CRT) remains a controversial strategy in the treatment of squamous cell cancer (SCC) and adenocarcinoma (ADC) of the oesophagus. Until recently, randomised studies mixed the two, often without any distinction. In randomised studies involving exclusively SCC, P-CRT increases the rate of local control, R0 resection, pCR and disease-free survival. The absence of any impact on overall survival may be linked to the toxic effects of this treatment. Meta-analyses have revealed...
