Cognitive effects of androgen deprivation therapy in an older cohort of men with prostate cancer
Supriya Gupta Mohile, Maureen Lacy, Miriam Rodin, Kathryn Bylow, William Dale, Michael R. Meager, Walter M. Stadler
20100701
2010 Aug 1
Crit Rev Oncol Hematol
Cognitive effects of androgen deprivation therapy in an older cohort of men with prostate cancer
Crit Rev Oncol Hematol. 2010 Aug;75(2):152-159, Supriya Gupta Mohile, Maureen Lacy, Miriam Rodin, Kathryn Bylow, William Dale, Michael R. Meager, Walter M. Stadler
Abstract
Abstract
ObjectiveTo determine the baseline prevalence of cognitive impairment in older men treated with ADT and to assess changes in cognitive performance over time.Methods and resultsThirty-two patients (median age of 71 years, range 51–87) were administrated an extensive neuropsychological testing battery prior to ADT initiation, with 21 (65%) completing post-treatment evaluations 6 months later. At baseline, 45% scored >1.5 standard deviations below the mean on ≥2 neuropsychological measures. Using standardized...
