Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: A new protein enters the scene
Davide Bolignano, Valentina Donato, Antonio Lacquaniti, Maria Rosaria Fazio, Caterina Bono, Giuseppe Coppolino, Michele Buemi
20100101
2010 Feb 1
Cancer Lett
Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: A new protein enters the scene
Cancer Lett. 2010 Feb 01;288(1):10-16, Davide Bolignano, Valentina Donato, Antonio Lacquaniti, Maria Rosaria Fazio, Caterina Bono, Giuseppe Coppolino, Michele Buemi
Abstract
Abstract
The small 25kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development.The aim of the present review is to point out the main contradictory, sometimes even paradoxical, effects attributed to NGAL in human neoplasias. For instance, acting as an intracellular iron carrier and protecting MMP9 from proteolytic...
