Molecular mechanisms underlying tumor dormancy
Nava Almog
20100701
2010 Aug 1
Cancer Lett
Molecular mechanisms underlying tumor dormancy
Cancer Lett. 2010 Aug 28;294(2):139-146, Nava Almog
ABSTRACT
Evidence suggests that dormant, microscopic tumors are not only common, but are highly prevalent in otherwise healthy individuals. Due to their small size and non-invasive nature, these dormant tumors remain asymptomatic and, in most cases, undetected. With advances in diagnostic imaging and molecular biology, it is now becoming clear that such neoplasms can remain in an asymptomatic, dormant stage for considerable periods of time without expanding in size. Although a number of processes may play...