Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology and oncogenesis
Kwun Wah Wen, Blossom Damania
20100201
2010 Mar 1
Cancer Lett
Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology and oncogenesis
Cancer Lett. 2010 Mar 28;289(2):140-150, Kwun Wah Wen, Blossom Damania
Abstract
Abstract
Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the γ-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment...
