Hunting for robust gene signature from cancer profiling data: Sources of variability, different interpretations, and recent methodological developments
Jian-zhen Xu, Chi-wai Wong
20100901
2010 Oct 1
Cancer Lett
Hunting for robust gene signature from cancer profiling data: Sources of variability, different interpretations, and recent methodological developments
Cancer Lett. 2010 Oct 01;296(1):9-16, Jian-zhen Xu, Chi-wai Wong
Abstract
Abstract
Gene microarray is a powerful platform to investigate the expression patterns of thousands of genes simultaneously. One central objective of such analysis is to select sets of genes (i.e., gene signatures) which correlate with clinical characteristics, such as disease subtype diagnosis, response to drug treatment and prognosis. However, previous studies have found that mRNA signatures are highly unstable and strongly depend on the selection of patient samples. Based on five large microRNA profiling...
