Genistein and hematological malignancies
Wang Li, Lynn T. Frame, Samantha Hirsch, Everardo Cobos
20100901
2010 Oct 1
Cancer Lett
Genistein and hematological malignancies
Cancer Lett. 2010 Oct 01;296(1):1-8, Wang Li, Lynn T. Frame, Samantha Hirsch, Everardo Cobos
Abstract
Abstract
Genistein is an isoflavanoid from soybeans and promising cancer chemotherapeutic agent. Genistein exposure varies widely because of cultural differences in diet. Hypothetically, this could account for differential cancer risk across ethnic populations. Genistein inhibits the growth of many different cancer cell lines by increasing apoptosis, inducing cell cycle delays, and modulating intracellular signaling pathways. Data from recent studies suggest that the therapeutic potential of genistein extends...