Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms
William Ka Kei Wu, Joseph Jao Yiu Sung, Chung Wa Lee, Jun Yu, Chi Hin Cho
20100801
2010 Sept 1
Cancer Lett
Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms
Cancer Lett. 2010 Sept 01;295(1):7-16, William Ka Kei Wu, Joseph Jao Yiu Sung, Chung Wa Lee, Jun Yu, Chi Hin Cho
Abstract
Abstract
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of NSAIDs is mediated through cyclooxygenase-2 (COX-2)-dependent and -independent regulation of oncogenic and tumor-suppressive pathways. Recent discoveries have shed new light on the regulation of COX-2 at the molecular level in these cancers. Moreover, prostaglandin E2 (PGE2), a COX-2-derived eicosanoid, has been found...
