JOURNAL SCANS

Our oncology experts identify the most important cancer-related articles from leading medical journals.

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Chemotherapy of Advanced Small-Bowel Adenocarcinoma: A Multicenter AGEO Study

A Zaanan, L Costes, M Gauthier, D Malka, C Locher, E Mitry, D Tougeron, T Lecomte, J-M Gornet, I Sobhani, V Moulin, P Afchain, J Taïeb, F Bonnetain, T Aparicio, 2010 Sept 1, Ann Oncol

In this retrospective analysis of 93 patients with advanced small-bowel adenocarcinoma, FOLFOX was associated with longer survival and was better tolerated than were other chemotherapy regimens. Access...

Overall Survival With Cisplatin–Gemcitabine and Bevacizumab or Placebo as First-Line Therapy for Nonsquamous Non-Small-Cell Lung Cancer: Results From a Randomised Phase III Trial (AVAiL)

M Reck, J von Pawel, P Zatloukal, R Ramlau, V Gorbounova, V Hirsh, N Leighl, J Mezger, V Archer, N Moore, C Manegold, BO17704 Study Group, 2010 Sept 1, Ann Oncol

Long-term follow-up data from AVAiL showed that addition of bevacizumab to first-line cisplatin/gemcitabine significantly prolonged progression-free survival, although it did not significantly lengthen... Access...

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

KT Flaherty, I Puzanov, KB Kim, A Ribas, GA McArthur, JA Sosman, PJ O'Dwyer, RJ Lee, JF Grippo, K Nolop, PB Chapman, 2010 Aug 26, N Engl J Med
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In this phase I study, PLX4032 induced responses in the majority of mutant BRAF-associated melanomas, representing a major advance for targeted therapy in this refractory disease. Access this article...

Trastuzumab in Combination With Chemotherapy Versus Chemotherapy Alone for Treatment of HER2-Positive Advanced Gastric or Gastro-Oesophageal Junction Cancer (ToGA): A Phase 3, Open-Label, Randomised Controlled Trial

Y-J Bang, E Van Cutsem, A Feyereislova, HC Chung, L Shen, A Sawaki, F Lordick, A Ohtsu, Y Omuro, T Satoh, G Aprile, E Kulikov, J Hill, M Lehle, J Rüschoff, Y-K Kang, for the ToGA Trial Investigators, 2010 Aug 20, Lancet

HER2 overexpression in patients with advanced gastric or gastroesophageal junction cancer predicted response to trastuzumab plus chemotherapy and extended survival. This regimen may become a new standard... Background:...

Detection of Extra-Axillary Lymph Node Involvement With FDG PET/CT in Patients With Stage II–III Breast Cancer

TS Aukema, ME Straver, M-J TFD Vrancken Peeters, NS Russell, KGA Gilhuijs, WV Vogel, EJT Rutgers, RA Valdés Olmos, 2010 Aug 18, Eur J Cancer

Journal Content FDG PET/CT may detect extra-axillary lymph node involvement in almost one-third of the patients with stage II–III breast cancer. These suspicious lymph nodes are as well located in several...

Reduced-Intensity Versus Conventional Myeloablative Conditioning Allogeneic Stem Cell Transplantation for Patients With Acute Lymphoblastic Leukemia: A Retrospective Study From the European Group for Blood and Marrow Transplantation

M Mohty, M Labopin, L Volin, A Gratwohl, G Socié, J Esteve, R Tabrizi, A Nagler, V Rocha, 2010 Aug 17, Blood

In this retrospective analysis of 576 adult patients with acute lymphoblastic leukemia ALL patients aged ≥45 year, investigators concluded that reduced-intensity conditioning is a feasible option for patients... This...

The Relationship Between New-Onset Diabetes Mellitus and Pancreatic Cancer Risk: A Case–Control Study

Q Ben, Q Cai, Z Li, Y Yuan, X Ning, S Deng, K Wang, 2010 Aug 16, Eur J Cancer

Journal Content Long-standing diabetes mellitus, but also new-onset diabetes, both appear to raise the risk of pancreatic ductal adenocarcinoma, independently of other known and suspected pancreatic cancer...

Vitamin D Insufficiency and Prognosis in Non-Hodgkin's Lymphoma

MT Drake, MJ Maurer, BK Link, TM Habermann, SM Ansell, IN Micallef, JL Kelly, WR Macon, GS Nowakowski, DJ Inwards, PB Johnston, RJ Singh, C Allmer, SL Slager, GJ Weiner, TE Witzig, JR Cerhan, 2010 Aug 16, J Clin Oncol

Vitamin D insufficiency predicted poor event-free and overall survival in two aggressive subtypes of non-Hodgkin’s lymphoma. Access this article » ...

Benefit of Consolidative Radiation Therapy in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP Chemotherapy

J Phan, A Mazloom, LJ Medeiros, TG Zreik, C Wogan, F Shihadeh, MA Rodriguez, L Fayad, N Fowler, V Reed, P Horace, BS Dabaja, 2010 Aug 16, J Clin Oncol

In this single-center, retrospective analysis of 469 patients with DLBCL, addition of consolidative radiation therapy to rituximab-containing therapy was associated with significantly improved survival,... Access...

Allogeneic Virus-Specific T Cells With HLA Alloreactivity Do Not Produce GVHD in Human Subjects

JJ Melenhorst, AM Leen, CM Bollard, MF Quigley, DA Price, CM Rooney, MK Brenner, AJ Barrett, HE Heslop, 2010 Aug 13, Blood

No significant increase in incidence of GVHD was reported in this study of 73 recipients of virus-specific cytotoxic T lymphocytes from HLA mismatched donors. Adoptive transfer of viral antigen-specific...
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Editors' Choice

Palliative Care With Chemotherapy Extends Survival in Metastatic NSCLC

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