JOURNAL SCANS

Our oncology experts identify the most important cancer-related articles from leading medical journals.

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FISH Analysis in Addition to G-Band Karyotyping: Utility in Evaluation of Myelodysplastic Syndromes?

W Yang, B Stotler, DW Sevilla, FN Emmons, VV Murty, B Alobeid, G Bhagat, 2010 Apr 1, Leuk Res

Journal Content A study of 110 patients with myelodysplastic syndrome evaluates the diagnostic and prognostic utility of adding a tailored FISH panel to G-band karyotyping. Cytogenetic analysis provides...

Vaginal Brachytherapy Versus Pelvic External Beam Radiotherapy for Patients With Endometrial Cancer of High-Intermediate Risk (PORTEC-2)

RA Nout, VTHBM Smit, H Putter, IM Jürgenliemk-Schulz, JJ Jobsen, LCHW Lutgens, EM van der Steen-Banasik, JWM Mens, A Slot, MC Stenfert Kroese, BNFM van Bunningen, AC Ansink, WLJ van Putten, CL Creutzberg, for the PORTEC Study Group, 2010 Mar 6, Lancet

Journal Content Vaginal brachytherapy (VBT) is as effective as pelvic external beam radiotherapy (EBRT) in preventing vaginal recurrence and is associated with less gastrointestinal toxicity. Background:...

Multilineage Dysplasia Has No Impact on Biological, Clinico-Pathological and Prognostic Features of AML With Mutated Nucleophosmin (NPM1)

B Falini, K Macijewski, T Weiss, U Bacher, S Schnittger, W Kern, A Kohlmann, H-U Klein, M Vignetti, A Piciocchi, P Fazi, MP Martelli, A Vitale, S Pileri, M Miesner, A Santucci, C Haferlach, F Mandelli, T Haferlach, 2010 Mar 4, Blood

Study clarifies the diagnostic and prognostic significance of multilineage dysplasia in NPM1-mutated acute myelogenous leukemia. NPM1-mutated AML is a provisional entity in the 2008 WHO classification...

Chemoradiation in Locally Advanced Cervical Carcinoma: An Analysis of Cisplatin Dosing and Other Clinical Prognostic Factors

EK Nugent, AS Case, JT Hoff, I Zighelboim, LL DeWitt, K Trinkhaus, DG Mutch, PH Thaker, LS Massad, JS Rader, 2010 Mar 1, Gynecol Oncol

The number of cisplatin chemotherapy cycles completed was independently predictive of PFS and OS, underscoring the importance of aggressive supportive care to maximize patients’ ability to tolerate tr... Objectives:...

Frequency of Screening Magnetic Resonance Imaging to Detect Occult Spinal Cord Compromise and to Prevent Neurological Deficit in Metastatic Castration-Resistant Prostate Cancer

R Venkitaraman, SA Sohaib, Y Barbachano, CC Parker, RA Huddart, A Horwich, D Dearnaley, 2010 Mar 1, Clin Oncol

Serial MRI screening of the spine detects clinically occult spinal cord compression. The recommended frequency of screening depends on the specific patient subset. Aims: Neurological deficit from malignant...

Is There a Role for Adjuvant Hysterectomy After Suboptimal Concurrent Chemoradiation in Cervical Carcinoma?

N Walji, AL Chue, C Yap, LJ Rogers, A El-Modir, KK Chan, K Singh, IN Fernando, 2010 Mar 1, Clin Oncol

Adjuvant hysterectomy after unsuccessful intracavitary brachytherapy reduced recurrence of cervical cancer and, at approximately 5 years of follow-up, did not appear to increase late toxicity. Aims: Failure...

Evaluation of Enteropathy Associated T-Cell Lymphoma Comparing Standard Therapies With a Novel Regimen Including Autologous Stem Cell Transplant

M Sieniawski, N Angamuthu, K Boyd, R Chasty, J Davies, P Forsyth, F Jack, S Lyons, P Mounter, P Revell, SJ Proctor, AL Lennard, 2010 Mar 2, Blood

Aggressive chemotherapy plus autologous stem cell transplantation (ASCT) improved survival over that with anthracycline-based chemotherapy for patients with enteropathy associated T-cell lymphoma. Enteropathy...

Adjuvant Chemoradiotherapy After Pancreatic Resection for Invasive Carcinoma Associated With Intraductal Papillary Mucinous Neoplasm of the Pancreas

MJ Swartz, CC Hsu, TM Pawlik, J Winter, RH Hruban, M Guler, RD Schulick, JL Cameron, DA Laheru, CL Wolfgang, JM Herman, 2010 Mar 1, Int J Radiat Oncol Biol Phys

Adjuvant chemoradiotherapy improved survival for patients with intraductal papillary mucinous neoplasms demonstrating an invasive component. Purpose: Intraductal papillary mucinous neoplasms are mucin-producing...

Lynch Syndrome Among Gynecologic Oncology Patients Meeting Bethesda Guidelines for Screening

CS Walsh, A Blum, A Walts, R Alsabeh, H Tran, HP Koeffler, BY Karlan, 2010 Mar 1, Gynecol Oncol

This study confirms the higher prevalence of Lynch syndrome in patients with early-onset endometrial cancer and the presence of synchronous Lynch syndrome-related cancers. A diagnostic algorithm helps... Objective:...

Outcome of Transplantation for Myelofibrosis

KK Ballen, S Shrestha, KA Sobocinski, M-J Zhang, A Bashey, BJ Bolwell, F Cervantes, SM Devine, RP Gale, V Gupta, TE Hahn, WJ Hogan, N Kröger, MR Litzow, DI Marks, RT Maziarz, PL McCarthy, G Schiller, HC Schouten, V Roy, PH Wiernik, MM Horowitz, SA Giralt, M Arora, 2010 Mar 1, Biol Blood Marrow Transplant

Approximately one-third of patients were alive at 5 years following allogeneic transplantation, including transplantation using reduced-intensity conditioning. Myelofibrosis is a myeloproliferative disorder...

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