Journal Scans
Vaginal Brachytherapy Versus Pelvic External Beam Radiotherapy for Patients With Endometrial Cancer of High-Intermediate Risk (PORTEC-2): An Open-Label, Non-inferiority, Randomised Trial
Vaginal Brachytherapy vs Pelvic EBRT for Endometrial Cancer
RA Nout, VTHBM Smit, H Putter, IM Jürgenliemk-Schulz, JJ Jobsen, LCHW Lutgens, EM van der Steen-Banasik, JWM Mens, A Slot, MC Stenfert Kroese, BNFM van Bunningen, AC Ansink, WLJ van Putten, CL Creutzberg, for the PORTEC Study Group
20100206
2010 Mar 6
Lancet
Vaginal Brachytherapy Versus Pelvic External Beam Radiotherapy for Patients With Endometrial Cancer of High-Intermediate Risk (PORTEC-2): An Open-Label, Non-inferiority, Randomised Trial
Lancet. 2010 Mar 6;375(9717):816-823, RA Nout, VTHBM Smit, H Putter, IM Jürgenliemk-Schulz, JJ Jobsen, LCHW Lutgens, EM van der Steen-Banasik, JWM Mens, A Slot, MC Stenfert Kroese, BNFM van Bunningen, AC Ansink, WLJ van Putten, CL Creutzberg, for the PORTEC Study Group
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Abstract
Abstract
Background: After surgery for intermediate-risk endometrial carcinoma, the vagina is the most frequent site of recurrence. This study established whether vaginal brachytherapy (VBT) is as effective as pelvic external beam radiotherapy (EBRT) in prevention of vaginal recurrence, with fewer adverse effects and improved quality of life. Methods: In this open-label, non-inferiority, randomised trial undertaken in 19 Dutch radiation oncology centres, 427 patients with stage I or IIA endometrial carcinoma...
