Two Cycles of Escalated BEACOPP Followed by Four Cycles of ABVD Utilizing Early-Interim PET/CT Scan Is an Effective Regimen for Advanced High-Risk Hodgkin's Lymphoma

Ann Oncol. 2010 Jan 1;[Epub Ahead of Print], A Avigdor, S Bulvik, I Levi, EJ Dann, N Shemtov, G Perez-Avraham, A Shimoni, A Nagler, I Ben-Bassat, A Polliack

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Abstract

SUMMARY

OncologySTAT Editorial Team

Escalated (esc) combination therapy with bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (escBEACOPP) is a powerful chemotherapy regimen. In the treatment of advanced Hodgkin’s lymphoma (HL), it has improved tumor control and overall survival (OS) vs treatment with baseline BEACOPP plus cyclophosphamide, vincristine, procarbazine, and prednisone alternating with doxorubicin, bleomycin, vinblastine, and dacarbazine (COPP/ABVD). High levels of toxicity...

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