Early-Stage, Lymphocyte-Predominant Hodgkin's Lymphoma: Patient Outcomes From a Large, Single-Institution Series With Long Follow-Up

J Clin Oncol. 2009 Nov 23; Epub ahead of print, RC Chen, MS Chin, AK Ng, Y Feng, D Neuberg, B Silver, GS Pinkus, M Ann Stevenson, PM Mauch

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Abstract

SUMMARY

OncologySTAT Editorial Team

Lymphocyte-predominant Hodgkin’s lymphoma (LPHL), a rare type of Hodgkin’s lymphoma (HL), has several defining features that distinguish it from classic HL. Morphologically, LPHL exhibits a nodular pattern of lymphocytic and histiocytic (L and H) cells, as opposed to the Reed-Sternberg cells that characterize classic HL. In addition to morphologic characterization, immunohistochemical analysis is needed to distinguish LPHL from classic HL. In LPHL, malignant cells in LPHL stain positive for CD19,...

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