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The Persistence of Immunophenotypically Normal Residual Bone Narrow Plasma Cells at Diagnosis Identifies a Good Prognostic Subgroup of Symptomatic Multiple Myeloma Patients
Normal Marrow Plasma Cells at MM Diagnosis Signify Better Prognosis
B Paiva, M-B Vidriales, G Mateo, JJ Perez, MA Montalban, A Sureda, L Montejano, NC Gutierrez, A Garcia de Coca, N de las Heras, MV Mateos, MC Lopez-Berges, R Garcia-Boyero, J Galende, J Hernandez, L Palomera, D Carrera, R Martinez, J de la Rubia, A Martin, Y Gonzalez, J Blade, JJ Lahuerta, A Orfao, JF San Miguel
20090815
2009 Sept 15
Blood
The Persistence of Immunophenotypically Normal Residual Bone Narrow Plasma Cells at Diagnosis Identifies a Good Prognostic Subgroup of Symptomatic Multiple Myeloma Patients
Blood. 2009 Sept 15; Epub ahead of print, B Paiva, M-B Vidriales, G Mateo, JJ Perez, MA Montalban, A Sureda, L Montejano, NC Gutierrez, A Garcia de Coca, N de las Heras, MV Mateos, MC Lopez-Berges, R Garcia-Boyero, J Galende, J Hernandez, L Palomera, D Carrera, R Martinez, J de la Rubia, A Martin, Y Gonzalez, J Blade, JJ Lahuerta, A Orfao, JF San Miguel
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Abstract
Abstract
Multiparameter flow cytometry (MFC) immunophenotyping allows discrimination between normal (N-PC) and myelomatous (MM-PC) plasma cells (PCs) within the bone marrow plasma cell compartment (BMPC). Here we report on the prognostic relevance of detecting >5% residual N-PC/BMPC by MFC in a series of 594 newly diagnosed symptomatic MM patients, uniformly treated according to the GEM2000 protocol. Our results show that symptomatic MM patients with >5%N-PC/BMPC (N=80/594; 14%) have a favorable baseline...
