Journal Scans
T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics and outcome from the large randomised prospective trial (UKALL XII/ECOG 2993)
Clinical Features and Outcomes in Adult T-Cell ALL
DI Marks, EM Paietta, AV Moorman, SM Richards, G Buck, G Dewald, A Ferrando, AK Fielding, AH Goldstone, RP Ketterling, MR Litzow, SM Luger, AK McMillan, M Mansour, JM Rowe, MS Tallman, HM Lazarus
20090914
2009 Oct 14
Blood
T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics and outcome from the large randomised prospective trial (UKALL XII/ECOG 2993)
Blood. 2009 Oct 14; Epub ahead of print, DI Marks, EM Paietta, AV Moorman, SM Richards, G Buck, G Dewald, A Ferrando, AK Fielding, AH Goldstone, RP Ketterling, MR Litzow, SM Luger, AK McMillan, M Mansour, JM Rowe, MS Tallman, HM Lazarus
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Abstract
Abstract
The biology and outcome of adult T-cell acute lymphoblastic leukemia are poorly understood. We present here the clinical and biological features of 356 patients treated uniformly on the prospective trial (UKALL XII/ECOG 2993) with the aim of describing the outcome and identifying prognostic factors. Complete remission was obtained in 94% of patients and 48% survived 5 years. Positivity of blasts for CD1a and lack of expression of CD13 were associated with better survival (p=0.01 and 0.0005 respectively)....
