Journal Scans
Systemic Chemotherapy and Surgical Cytoreduction for Poorly Differentiated and Signet Ring Cell Adenocarcinomas of the Appendix
Treatment Options for Biologically Aggressive Appendix Tumors
CH Lieu, LA Lambert, RA Wolff, C Eng, N Zhang, S Wen, S Rafeeq, M Taggart, K Fournier, R Royal, P Mansfield, MJ Overman
20110508
2011 Jun 8
Ann Oncol
Systemic Chemotherapy and Surgical Cytoreduction for Poorly Differentiated and Signet Ring Cell Adenocarcinomas of the Appendix
Ann Oncol. 2011 Jun 8;[Epub Ahead of Print], CH Lieu, LA Lambert, RA Wolff, C Eng, N Zhang, S Wen, S Rafeeq, M Taggart, K Fournier, R Royal, P Mansfield, MJ Overman
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Abstract
SUMMARY
OncologySTAT Editorial Team
Appendiceal adenocarcinomas are a rare and histologically diverse group of cancers; patient prognosis varies significantly by tumor biology. Most of these tumors are slow growing and do not develop extraperitoneal metastases, and the standard treatment is complete cytoreductive surgery (CRS), followed by hyperthermic intraperitoneal chemotherapy. Tumors with poorly differentiated or signet ring cell histology, however, tend to be more aggressive, with studies suggesting worse outcomes for patients...
