Journal Scans
Strikingly Different Molecular Relapse Kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 Acute Myeloid Leukemias
Molecular Relapse Kinetics Differ in Acute Myeloid Leukemias
H Beier Ommen, S Schnittger, JV Jovanovic, I Beier Ommen, H Hasle, M Østergaard, D Grimwade, P Hokland
20100001
2010 Jan 1
Blood
Strikingly Different Molecular Relapse Kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 Acute Myeloid Leukemias
Blood. 2010 Jan 1;115(2):198-205, H Beier Ommen, S Schnittger, JV Jovanovic, I Beier Ommen, H Hasle, M Østergaard, D Grimwade, P Hokland
TAKE-HOME MESSAGE
Abstract
Abstract
Early relapse detection in acute myeloid leukemia is possible using standardized real-time quantitative polymerase chain reaction (RQ-PCR) protocols. However, optimal sampling intervals have not been defined and are likely to vary according to the underlying molecular lesion. In 74 patients experiencing hematologic relapse and harboring aberrations amenable to RQ-PCR (mutated NPM1 [designated NPM1c], PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11), we observed strikingly different relapse kinetics. The...
