Journal Scans
Sonographic and Electrodiagnostic Evaluations in Patients With Aromatase Inhibtor-Related Arthralgia
Rheumatologic Assessment of Arthralgia in Patients on Aromatase Inhibitors
O Dizdar, L Özçakar, FÜ Malas, H Harputluoglu, N Bulut, S Aksoy, Y Ozisik, K Altundag
20090814
2009 Sept 14
J Clin Oncol
Sonographic and Electrodiagnostic Evaluations in Patients With Aromatase Inhibtor-Related Arthralgia
J Clin Oncol. 2009 Sept 14; Epub ahead of print, O Dizdar, L Özçakar, FÜ Malas, H Harputluoglu, N Bulut, S Aksoy, Y Ozisik, K Altundag
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Abstract
SUMMARY
OncologySTAT Editorial Team
Aromatase inhibitors (AIs) block the aromatase enzyme, therefore effectively reducing the levels of estrogen in postmenopausal women. Several clinical trials have shown the superiority of AIs over tamoxifen, leading to their use as the gold standard for adjuvant endocrine therapy in postmenopausal women with breast cancer. Compared with tamoxifen, AIs are associated with a greater frequency of musculoskeletal events, including arthralgias, loss of bone mineral density, and fractures. The fractures...
