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Signet Ring Cell Histology Is an Independent Predictor of Poor Prognosis in Gastric Adenocarcinoma Regardless of Tumoral Clinical Presentation
Signet Ring Cell Histology and Prognosis in Gastric Adenocarcinoma
G Piessen, M Messager, E Leteurtre, T Jean-Pierre, C Mariette
20091101
2009 Dec 1
Ann Surg
Signet Ring Cell Histology Is an Independent Predictor of Poor Prognosis in Gastric Adenocarcinoma Regardless of Tumoral Clinical Presentation
Ann Surg. 2009 Dec 1;250(6):878-887, G Piessen, M Messager, E Leteurtre, T Jean-Pierre, C Mariette
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Abstract
Abstract
Objective: To test the hypothesis that signet ring cell (SRC) histology has a negative prognostic value in patients with gastric adenocarcinoma (ADC). Summary Background Data: In western countries, gastric ADC with SRC often occurs after the disease has advanced. Consequently, the prognosis of SRC is generally regarded as poor, although survival studies comparing SRC and non-SRC have yielded inconsistent results.Methods: An intent to treat analysis was performed among 215 patients with gastric...
