Journal Scans
Sequential Adjuvant Chemotherapy and Radiotherapy in Endometrial Cancer—Results From Two Randomised Studies
Chemotherapy Plus Radiotherapy in High-Risk Endometrial Cancer
T Hogberg, M Signorelli, CF de Oliveira, R Fossati, AA Lissoni, B Sorbe, H Andersson, S Grenman, C Lundgren, P Rosenberg, K Boman, B Tholander, G Scambia, N Reed, G Cormio, G Tognon, J Clarke, T Sawicki, P Zola, G Kristensen
20100601
2010 Jul 1
Eur J Cancer
Sequential Adjuvant Chemotherapy and Radiotherapy in Endometrial Cancer—Results From Two Randomised Studies
Eur J Cancer. 2010 Jul 1;[Epub Ahead of Print], T Hogberg, M Signorelli, CF de Oliveira, R Fossati, AA Lissoni, B Sorbe, H Andersson, S Grenman, C Lundgren, P Rosenberg, K Boman, B Tholander, G Scambia, N Reed, G Cormio, G Tognon, J Clarke, T Sawicki, P Zola, G Kristensen
TAKE-HOME MESSAGE
Abstract
Abstract
Introduction: Endometrial cancer patients with high grade tumours, deep myometrial invasion or advanced stage disease have a poor prognosis. Randomised studies have demonstrated the prevention of loco-regional relapses with radiotherapy (RT) with no effect on overall survival (OS). The possible additive effect of chemotherapy (CT) remains unclear. Two randomised clinical trials (NSGO-EC-9501/EORTC-55991 and MaNGO ILIADE-III) were undertaken to clarify if sequential combination of chemotherapy and...
