Journal Scans
Reduced Treatment Intensity in Patients with Early-Stage Hodgkin's Lymphoma
Reduced Intensity Regimens Are Effective in Early-Stage Hodgkin’s Lymphoma
A Engert, A Plütschow, H Theodor Eich, A Lohri, B Dörken, P Borchmann, B Berger, R Greil, KC Willborn, M Wilhelm, J Debus, MJ Eble, M Sökler, A Ho, A Rank, A Ganser, L Trümper, C Bokemeyer, H Kirchner, J Schubert, Z Král, M Fuchs, H-K Müller-Hermelink, R-P Müller, V Diehl
Yes
20100712
2010 Aug 12
N Engl J Med
Reduced Treatment Intensity in Patients with Early-Stage Hodgkin's Lymphoma
N Engl J Med. 2010 Aug 12;363640-652, A Engert, A Plütschow, H Theodor Eich, A Lohri, B Dörken, P Borchmann, B Berger, R Greil, KC Willborn, M Wilhelm, J Debus, MJ Eble, M Sökler, A Ho, A Rank, A Ganser, L Trümper, C Bokemeyer, H Kirchner, J Schubert, Z Král, M Fuchs, H-K Müller-Hermelink, R-P Müller, V Diehl
TAKE-HOME MESSAGE
EXPERT COMMENTARY
Abstract
SUMMARY
OncologySTAT Editorial Team
The mainstay of therapy for patients with favorable-prognosis, early-stage Hodgkin’s lymphoma (HL) is four cycles of chemotherapy (CT) consisting of doxorubicin, bleomycen, vinblastine, and dacarbazine (ABVD) followed by involved-field radiotherapy (IFRT) at a dose of 30 Gy. Reducing the intensity of therapy would be desirable to decrease toxicity. It is yet unknown whether reducing the number of CT cycles or the IFRT dose will reduce efficacy. The German Hodgkin’s Study Group conducted a large,...
