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Reduced-Intensity Versus Conventional Myeloablative Conditioning Allogeneic Stem Cell Transplantation for Patients With Acute Lymphoblastic Leukemia: A Retrospective Study From the European Group for Blood and Marrow Transplantation
Reduced-Intensity Myeloablative Conditioning Proves Acceptable in ALL
M Mohty, M Labopin, L Volin, A Gratwohl, G Socié, J Esteve, R Tabrizi, A Nagler, V Rocha
20100717
2010 Aug 17
Blood
Reduced-Intensity Versus Conventional Myeloablative Conditioning Allogeneic Stem Cell Transplantation for Patients With Acute Lymphoblastic Leukemia: A Retrospective Study From the European Group for Blood and Marrow Transplantation
Blood. 2010 Aug 17;[Epub Ahead of Print], M Mohty, M Labopin, L Volin, A Gratwohl, G Socié, J Esteve, R Tabrizi, A Nagler, V Rocha
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Abstract
Abstract
This retrospective study assessed the outcome of 576 adult ALL patients aged ≥45, and who received a reduced-intensity (RIC; n=127) or a myeloablative conditioning (MAC; n=449) allogeneic stem cell transplantation (allo-SCT) from an HLA-identical sibling while in complete remission. With a median follow-up of 16 months, at 2 years, the cumulative incidences of non-relapse mortality (NRM) and relapse (RI) were 29±2% (MAC) vs. 21±5% (RIC; P=0.03), and 31±2% (MAC) vs. 47±5% (RIC; P<0.001) respectively....
