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Radiation Therapy and Tamoxifen After Breast-Conserving Surgery: Updated Results of a 2 × 2 Randomised Clinical Trial in Patients With Low Risk of Recurrence
RT Plus Tamoxifen After Breast-Conserving Surgery in Low-Recurrence-Risk Patients
KJ Winzer, W Sauerbrei, M Braun, T Liersch, J Dunst, H Guski, M Schumacher, for the German Breast Cancer Study Group (GBSG)
20100001
2010 Jan 1
Eur J Cancer
Radiation Therapy and Tamoxifen After Breast-Conserving Surgery: Updated Results of a 2 × 2 Randomised Clinical Trial in Patients With Low Risk of Recurrence
Eur J Cancer. 2010 Jan 1;46(1):95-101, KJ Winzer, W Sauerbrei, M Braun, T Liersch, J Dunst, H Guski, M Schumacher, for the German Breast Cancer Study Group (GBSG)
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Abstract
Abstract
To study the role of radiotherapy and tamoxifen after breast-conserving surgery (BCS) in patients with a favourable prognosis, a clinical trial was initiated by the German Breast Cancer Study Group (GBSG-V). Between 1991 and 1998, 361 patients (pT 1pN0M0, aged 45–75 years, receptor positive, grades I and II) were randomised to radiotherapy (yes/no) and tamoxifen for 2 years (yes/no) in a 2 • 2-factorial design; the exclusion of seven centres (14 patients) left 347 patients for the analysis. First...
