Journal Scans
Poor Prognosis Nonseminomatous Germ-Cell Tumours (NSGCTs): Should Chemotherapy Doses Be Reduced at First Cycle to Prevent Acute Respiratory Distress Syndrome in Patients With Multiple Lung Metastases?
Adjusting Chemotherapy for Patients With NSGCTs and Lung Metastases
C Massard, A Plantade, M Gross-Goupil, Y Loriot, B Besse, B Raynard, F Blot, S Antoun, G Nitenberg, B Escudier, K Fizazi
20100701
2010 Aug 1
Ann Oncol
Poor Prognosis Nonseminomatous Germ-Cell Tumours (NSGCTs): Should Chemotherapy Doses Be Reduced at First Cycle to Prevent Acute Respiratory Distress Syndrome in Patients With Multiple Lung Metastases?
Ann Oncol. 2010 Aug 1;211585-1588, C Massard, A Plantade, M Gross-Goupil, Y Loriot, B Besse, B Raynard, F Blot, S Antoun, G Nitenberg, B Escudier, K Fizazi
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Abstract
SUMMARY
OncologySTAT Editorial Team
In patients with nonseminomatous germ-cell tumors (NSGCT) who have extensive lung metastases, induction chemotherapy may lead to complications typical of acute respiratory distress syndrome (ARDS). These complications include intra-alveolar hemorrhage, tumor necrosis, and subsequent superinfection promoted by neutropenia. Currently, there is no firm, evidence-based recommendation for treating such patients. In 1997, investigators at the Institut Gustave Roussy in France modified their therapeutic...
