Perineural Invasion Is an Independent Predictor of Outcome in Colorectal Cancer

J Clin Oncol. 2009 Sept 8;[Epub Ahead of Print], C Liebig, G Ayala, J Wilks, G Verstovsek, H Liu, N Agarwal, DH Berger, D Albo

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Abstract

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OncologySTAT Editorial Team

Patients with node-negative colorectal cancer are not usually treated with chemotherapy. However, because many such patients nevertheless experience disease recurrence, identification of factors associated with recurrence or poor outcomes may be useful in identifying which node-negative patients may benefit from adjuvant therapy. Tumor invasion of peripheral nervous system structures has been associated with worse prognosis and a more aggressive tumor phenotype in several cancers. This retrospective...

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