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Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and the MYC and MYCN Loci
DNA Copy-Number Aberrations Predict Outcomes in Pediatric Medulloblastoma
S Pfister, M Remke, A Benner, F Mendrzyk, G Toedt, J Felsberg, A Wittmann, F Devens, NU Gerber, S Joos, A Kulozik, G Reifenberger, S Rutkowski, OD Wiestler, B Radlwimmer, W Scheurlen, P Lichter, A Korshunov
20090202
2009 Mar 2
J Clin Oncol
Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and the MYC and MYCN Loci
J Clin Oncol. 2009 Mar 2;[Epub ahead of print], S Pfister, M Remke, A Benner, F Mendrzyk, G Toedt, J Felsberg, A Wittmann, F Devens, NU Gerber, S Joos, A Kulozik, G Reifenberger, S Rutkowski, OD Wiestler, B Radlwimmer, W Scheurlen, P Lichter, A Korshunov
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Abstract
SUMMARY
OncologySTAT Editorial Team
Medulloblastoma is the most common childhood brain malignancy. Treatment is curative in approximately 60% of children but is associated with severe long-term sequelae. Unfortunately, 10% to 15% of children afflicted with medulloblastoma will survive <2 years. Risk stratification is based on clinical factors (ie, age at diagnosis, metastatic stage at diagnosis, extent of resection, and histologic type). Evidence suggests that incorporating molecular markers into risk assessment models would enhance...
