Oral Bisphosphonate Use and Breast Cancer Incidence in Postmenopausal Women

J Clin Oncol. 2010 Jun 21;[Epub Ahead of Print], RT Chlebowski, Z Chen, JA Cauley, G Anderson, RJ Rodabough, A McTiernan, DS Lane, JE Manson, L Snetselaar, S Yasmeen, MJ O'Sullivan, M Safford, SL Hendrix, RB Wallace

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Abstract

SUMMARY

OncologySTAT Editorial Team

Oral bisphosphonates are commonly used to treat osteoporosis and reduce skeletal-related complications in cancer patients with bone metastases. Recent evidence suggests that these agents may inhibit breast cancer and reduce recurrences. Chlebowski et al studied the possible connection between bisphosphonate use and breast cancer incidence in postmenopausal women with no prior history of breast cancer or use of tamoxifen/raloxifene. The women were enrolled in the Women’s Health Initiative (WHI) observational...

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