Nonmelanoma Skin Cancer and Risk for Subsequent Malignancy
J Natl Cancer Inst. 2008 Sept 3;100(17):1215-1222, J Chen, I Ruczinski, TJ Jorgensen, G Yenokyan, Y Yao, R Alani, NJ Liegeois, SC Hoffman, J Hoffman-Bolton, PT Strickland, KJ Helzlsouer, AJ Alberg
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Abstract
Abstract
BACKGROUND: Individuals with a personal history of nonmelanoma skin cancer (NMSC) may have an increased risk of subsequent noncutaneous malignancies. To test this hypothesis, we carried out a community-based, prospective cohort study. METHODS: In the CLUE (Give Us a Clue to Cancer and Heart Disease) II cohort, which was established in Washington County, MD, in 1989, the risk of new malignancies was compared among individuals with (n = 769) and without (n = 18,405) a personal history of NMSC (total...
SUMMARY
OncologySTAT Editorial Team
Basal cell carcinoma and squamous cell carcinoma, combined, are diagnosed in >1 million people in the United States annually. These 2 malignancies, referred to as nonmelanoma skin cancer (NMSC), cause >1000 deaths each year and are a major source of morbidity. The likelihood that individuals will develop NMSC appears to depend largely on their cumulative exposure to ultraviolet radiation from the sun. People who are more apt to develop skin burns when they are exposed to sunlight are more susceptible...
