Journal Scans
Multilineage Dysplasia Has No Impact on Biological, Clinico-Pathological and Prognostic Features of AML With Mutated Nucleophosmin (NPM1)
Prognostic Significance of Multilineage Dysplasia in NPM1-Mutated AML
B Falini, K Macijewski, T Weiss, U Bacher, S Schnittger, W Kern, A Kohlmann, H-U Klein, M Vignetti, A Piciocchi, P Fazi, MP Martelli, A Vitale, S Pileri, M Miesner, A Santucci, C Haferlach, F Mandelli, T Haferlach
20100204
2010 Mar 4
Blood
Multilineage Dysplasia Has No Impact on Biological, Clinico-Pathological and Prognostic Features of AML With Mutated Nucleophosmin (NPM1)
Blood. 2010 Mar 4; Epub online ahead of print, B Falini, K Macijewski, T Weiss, U Bacher, S Schnittger, W Kern, A Kohlmann, H-U Klein, M Vignetti, A Piciocchi, P Fazi, MP Martelli, A Vitale, S Pileri, M Miesner, A Santucci, C Haferlach, F Mandelli, T Haferlach
TAKE-HOME MESSAGE
Abstract
Abstract
NPM1-mutated AML is a provisional entity in the 2008 WHO classification of myeloid neoplasms. The significance of multilineage dysplasia (MLD) in NPM1-mutated AML is unclear. Thus, in 2008 WHO classification, NPM1-mutated AML with MLD is classified as AML with myelodysplasia (MD)-related changes (MRC). We evaluated morphologically 318 NPM1-mutated AML patients and found MLD in 23.3% of them. Except for a slight male predominance and a lower FLT3-ITD incidence in MLD+ group, no differences were observed...
