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Monoclonal Gammopathy of Undetermined Significance and Risk of Skeletal Fractures: A Population-Based Study
MGUS and Risk of Skeletal Fractures
SY Kristinsson, M Tang, RM Pfeiffer, M Björkholm, C Blimark, U-H Mellqvist, A Wahlin, I Turesson, O Landgren
20100607
2010 Jul 7
Blood
Monoclonal Gammopathy of Undetermined Significance and Risk of Skeletal Fractures: A Population-Based Study
Blood. 2010 Jul 7;[Epub Ahead of Print], SY Kristinsson, M Tang, RM Pfeiffer, M Björkholm, C Blimark, U-H Mellqvist, A Wahlin, I Turesson, O Landgren
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Abstract
Abstract
Patients with multiple myeloma (MM) have an increased risk of fractures. Based on small numbers, patients with monoclonal gammopathy of undetermined significance (MGUS) have been reported to have an increased fracture risk. Using population-based data from Sweden, we assessed the risks of fractures in 5,326 MGUS patients diagnosed 1958-2006, compared to 20,161 matched controls. MGUS patients had an increased risk of any fracture at 5 (hazard ratios (HR)=1.74; 95% confidence intervals (CI) 1.58-1.92),...
