Journal Scans
Low p27 Expression Predicts Early Relapse and Death in Postmenopausal Hormone Receptor–Positive Breast Cancer Patients Receiving Adjuvant Tamoxifen Therapy
Low p27 Expression Is Prognostic in Tamoxifen-Treated Postmenopausal HR+ Breast Cancer
M Filipits, M Rudas, H Heinzl, R Jakesz, E Kubista, S Lax, W Schippinger, O Dietze, R Greil, W Stiglbauer, W Kwasny, A Nader, M Stierer, MF Gnant
20090815
2009 Sept 15
Clin Cancer Res
Low p27 Expression Predicts Early Relapse and Death in Postmenopausal Hormone Receptor–Positive Breast Cancer Patients Receiving Adjuvant Tamoxifen Therapy
Clin Cancer Res. 2009 Sept 15;15(18):5888-5894, M Filipits, M Rudas, H Heinzl, R Jakesz, E Kubista, S Lax, W Schippinger, O Dietze, R Greil, W Stiglbauer, W Kwasny, A Nader, M Stierer, MF Gnant
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Abstract
SUMMARY
OncologySTAT Editorial Team
The p27Kip1 (p27) protein plays an important role in cell cycle regulation during the transition from G1 to S-phase. In many cancers, p27 is functionally inactivated via proteolysis and has been implicated in tumor progression. In breast cancer, aberrant p27 expression has been associated with poor outcome. Evidence suggests that cell cycle arrest by tamoxifen requires normal p27 expression. Results of recent studies showed that high p27 expression is independently predictive of improved relapse-free...
