Journal Scans
Long-Term Results of a Randomized Trial of Surgery With or Without Preoperative Chemotherapy in Esophageal Cancer
Preoperative Chemotherapy Improves Long-Term Survival in Esophageal Cancer
WH Allum, SP Stenning, J Bancewicz, PI Clark, RE Langley
20090821
2009 Sept 21
J Clin Oncol
Long-Term Results of a Randomized Trial of Surgery With or Without Preoperative Chemotherapy in Esophageal Cancer
J Clin Oncol. 2009 Sept 21; Epub ahead of print, WH Allum, SP Stenning, J Bancewicz, PI Clark, RE Langley
TAKE-HOME MESSAGE
Abstract
SUMMARY
OncologySTAT Editorial Team
Two large, long-term studies have compared the effectiveness of preoperative chemotherapy followed by surgery as opposed to surgery alone in patients with esophageal cancer. The initial results of the United Kingdom Medical Research Council trial (OEO2), after a median follow-up of 17 months, demonstrated that preoperative chemotherapy significantly increased disease-free and overall survival. In contrast, after a median follow-up of 4 years, a similar trial conducted in the United States (RTOG 8911)...
