Kaposi Sarcoma Incidence in the Swiss HIV Cohort Study Before and After Highly Active Antiretroviral Therapy
Br J Cancer. 2008 Sept 2;99(5):800-804, S Franceschi, L Dal Maso, M Rickenbach, J Polesel , B Hirschel, M Cavassini, A Bordoni, L Elzi, S Ess, G Jundt, N Mueller, GM Clifford, the Swiss HIV Cohort Study
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Abstract
Abstract
Between 1984 and 2006, 12 959 people with HIV/AIDS (PWHA) in the Swiss HIV Cohort Study contributed a total of 73 412 person-years (py) of follow-up, 35 551 of which derived from PWHA treated with highly active antiretroviral therapy (HAART). Five hundred and ninety-seven incident Kaposi sarcoma (KS) cases were identified of whom 52 were among HAART users. Cox regression was used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (CI). Kaposi sarcoma incidence fell abruptly...
SUMMARY
OncologySTAT Editorial Team
Kaposi sarcoma (KS) was commonly associated with acquired immune deficiency syndrome (AIDS) before widespread use of highly active antiretroviral therapy (HAART). This study used >20 years of follow-up data from the Swiss HIV Cohort Study (SHCS) to provide long-term epidemiologic data on patients with KS before and after HAART use. The incidence of KS declined substantially with HAART use. Factors associated with increased risk of KS included CD4 count <50 cells/mcL-1, antiretroviral treatment interruption,...
