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KRAS Mutation is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer
Mutant KRAS Associated With Lung, Brain Mets in CRC
J Tie, L Lipton, J Desai, P Gibbs, RN Jorissen, M Christie, KJ Drummond, BNJ Thomson, V Usatoff, PM Evans, AW Pick, S Knight, PWG Carne, R Berry, A Polglase, P McMurrick, Q Zhao, D Busam, RL Strausberg, E Domingo, IPM Tomlinson, R Midgley, D Kerr, O Sieber
Yes
20110014
2011 Jan 14
Clin Cancer Res
KRAS Mutation is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer
Clin Cancer Res. 2011 Jan 14;[Epub Ahead of Print], J Tie, L Lipton, J Desai, P Gibbs, RN Jorissen, M Christie, KJ Drummond, BNJ Thomson, V Usatoff, PM Evans, AW Pick, S Knight, PWG Carne, R Berry, A Polglase, P McMurrick, Q Zhao, D Busam, RL Strausberg, E Domingo, IPM Tomlinson, R Midgley, D Kerr, O Sieber
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Abstract
SUMMARY
OncologySTAT Editorial Team
Approximately 30% of patients with resectable colorectal cancer will present with distant recurrence, commonly located in the liver, lung, and peritoneum. Thus, ongoing surveillance of the abdomen and chest are recommended for these patients. Mutations in genes involved in the mitogen-activated kinase (MAPK) pathway (ie, BRAF, KRAS, NRAS) and phosphatidylinositol 3-kinase pathway (ie, PIK3CA) are common in colorectal tumors. In this study, investigators evaluated the differences in mutation profiles...
