Journal Scans
Interim Positron Emission Tomography (PET) Scans in Diffuse Large B-Cell Lymphoma: An Independent Expert Nuclear Medicine Evaluation of the Eastern Cooperative Oncology Group E3404 Study
PET Interpretation in DLBCL Is Only Moderately Consistent
SJ Horning, ME Juweid, H Schoder, G Wiseman, A McMillan, LJ Swinnen, R Advani, R Gascoyne, A Quon
20090818
2009 Sept 18
Blood
Interim Positron Emission Tomography (PET) Scans in Diffuse Large B-Cell Lymphoma: An Independent Expert Nuclear Medicine Evaluation of the Eastern Cooperative Oncology Group E3404 Study
Blood. 2009 Sept 18; Epub ahead of print, SJ Horning, ME Juweid, H Schoder, G Wiseman, A McMillan, LJ Swinnen, R Advani, R Gascoyne, A Quon
TAKE-HOME MESSAGE
Abstract
Abstract
Positive interim-PET scans are thought to be associated with inferior outcomes in diffuse large B-cell lymphoma (DLBCL). In the E3404 DLBCL study, PET scans at baseline and after 3 R-CHOP were centrally reviewed by a single reader. To determine reproducibility of interim PET interpretation, an expert panel of 3 external nuclear medicine physicians visually scored baseline and interim-PET scans independently and blinded to clinical information. The binary ECOG study criteria were based on modifications...
