Journal Scans
Iniparib Plus Chemotherapy in Metastatic Triple-Negative Breast Cancer
Iniparib + GC Effective in Metastatic Triple-Negative Breast Cancer
J O’Shaughnessy, C Osborne, JE Pippen, M Yoffe, D Patt, C Rocha, I Chou Koo, BM Sherman, MC Bradley
Yes
20110005
2011 Jan 5
N Engl J Med
Iniparib Plus Chemotherapy in Metastatic Triple-Negative Breast Cancer
N Engl J Med. 2011 Jan 5;[Epub Ahead of Print], J O’Shaughnessy, C Osborne, JE Pippen, M Yoffe, D Patt, C Rocha, I Chou Koo, BM Sherman, MC Bradley
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Abstract
SUMMARY
OncologySTAT Editorial Team
Metastatic triple-negative breast cancer (TNBC; ie, hormone receptor– and HER2-negative disease) is an aggressive breast cancer subtype associated with poor survival and increased risk of visceral and central nervous system metastases when compared with hormone receptor–positive breast cancer. To date, no standard of care exists, and, thus, metastatic TNBC represents an unmet clinical need. Poly(adenosine diphosphate–ribose) polymerase (PARP) inhibition has been shown to improve survival in patients...
