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Influence of Pre- and Post-Transplantation Responses on Outcome of Patients With Multiple Myeloma: Sequential Improvement of Response and Achievement of Complete Response Are Associated With Longer Survival
Quality of Response to Transplantation Influences Survival
JJ Lahuerta, MV Mateos, J Martínez-López, L Rosiñol, A Sureda, J de la Rubia, J García-Laraña, R Martínez-Martínez, MT Hernández-García, D Carrera, J Besalduch, F de Arriba, JM Ribera, L Escoda B Hernández-Ruiz, J García-Frade, C Rivas-González, A Alegre, J Bladé, JF San Miguel
20081110
2008 Dec 10
J Clin Oncol
Influence of Pre- and Post-Transplantation Responses on Outcome of Patients With Multiple Myeloma: Sequential Improvement of Response and Achievement of Complete Response Are Associated With Longer Survival
J Clin Oncol. 2008 Dec 10;26(35):5775-5782, JJ Lahuerta, MV Mateos, J Martínez-López, L Rosiñol, A Sureda, J de la Rubia, J García-Laraña, R Martínez-Martínez, MT Hernández-García, D Carrera, J Besalduch, F de Arriba, JM Ribera, L Escoda B Hernández-Ruiz, J García-Frade, C Rivas-González, A Alegre, J Bladé, JF San Miguel
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Abstract
SUMMARY
OncologySTAT Editorial Team
In patients with multiple myeloma (MM), complete response (CR) to high-dose therapy plus stem cell transplantation (HDT/SCT) is defined as the absence of M-protein in serum and urine, currently as measured by immunofixation (IF). (Electrophoresis was previously used to detect M-protein.) A near-CR (nCR) is defined as a response that is IF positive but electrophoresis negative. This prospective study evaluated the prognostic strength of responses to the Grupo Español de Mieloma (GEM) 2000 protocol,...
