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Independent and Joint Effects of Serum 25-Hydroxyvitamin D and Calcium on Ovarian Cancer Risk: A Prospective Nested Case–Control Study
Vitamin D and Calcium Reduce Ovarian Cancer Risk
AT Toriola, H-M Surcel, A Calypse, K Grankvist, T Luostarinen, A Lukanova, E Pukkala, M Lehtinen
20100521
2010 Jun 21
Eur J Cancer
Independent and Joint Effects of Serum 25-Hydroxyvitamin D and Calcium on Ovarian Cancer Risk: A Prospective Nested Case–Control Study
Eur J Cancer. 2010 Jun 21;[Epub Ahead of Print], AT Toriola, H-M Surcel, A Calypse, K Grankvist, T Luostarinen, A Lukanova, E Pukkala, M Lehtinen
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Abstract
Abstract
Ovarian cancer has very few known modifiable risk factors but dietary studies suggest a role for vitamin D and calcium in the prevention of ovarian cancer. Thus, we investigated the association between pre-diagnostic serum calcium and 25-hydroxyvitamin D (25-OHD) on the risk of later development of ovarian cancer. Methods: We conducted a population-based nested case–control study within the Finnish Maternity Cohort (FMC). The cohort subset comprised 172 ovarian cancer cases with 172 matched controls...
