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Impact of Optimal Follow-up of Monoclonal Gammopathy of Undetermined Significance (MGUS) on Early Diagnosis and Prevention of Myeloma-Related Complications
Optimal Follow-up of MGUS for Early Myeloma Diagnosis
G Bianchi, RA Kyle, CL Colby, DR Larson, S Kumar, JA Katzmann, A Dispenzieri, TM Therneau, JR Cerhan, LJ Melton III, SV Rajkumar
20100421
2010 May 21
Blood
Impact of Optimal Follow-up of Monoclonal Gammopathy of Undetermined Significance (MGUS) on Early Diagnosis and Prevention of Myeloma-Related Complications
Blood. 2010 May 21;[Epub Ahead of Print], G Bianchi, RA Kyle, CL Colby, DR Larson, S Kumar, JA Katzmann, A Dispenzieri, TM Therneau, JR Cerhan, LJ Melton III, SV Rajkumar
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Abstract
Abstract
Monoclonal Gammopathy of Undetermined Significance (MGUS) is associated with a long-term risk of progression to multiple myeloma (MM) or related malignancy. In order to prevent serious myeloma-related complications, lifelong annual follow-up has been recommended, but its value is unknown. We reviewed all patients from southeastern Minnesota seen at Mayo Clinic between 1973 and 2004 with MGUS who subsequently progressed to MM. Of 116 patients, 69% had optimal follow-up of MGUS. Among these, abnormalities...
