Journal Scans
Imatinib Mesylate in Advanced Dermatofibrosarcoma Protuberans: Pooled Analysis of Two Phase II Clinical Trials
Imatinib Is Effective in Dermatofibrosarcoma Protuberans
P Rutkowski, M Van Glabbeke, C Rankin, W Ruka, B Rubin, M Debiec-Rychter, A Lazar, H Gelderblom, R Sciot, D Lopez-Terrada, P Hohenberger, A van Oosterom, S Schuetze
20100201
2010 Mar 1
Ann Oncol
Imatinib Mesylate in Advanced Dermatofibrosarcoma Protuberans: Pooled Analysis of Two Phase II Clinical Trials
Ann Oncol. 2010 Mar 1;21(3):540-547, P Rutkowski, M Van Glabbeke, C Rankin, W Ruka, B Rubin, M Debiec-Rychter, A Lazar, H Gelderblom, R Sciot, D Lopez-Terrada, P Hohenberger, A van Oosterom, S Schuetze
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Abstract
SUMMARY
OncologySTAT Editorial Team
Dermatofibrosarcoma protuberans (DFSP) is an uncommon type of tumor of the soft tissues comprising approximately 1% of all sarcomas. The growth of DFSP is usually indolent, with a <5% probability of metastasis. The most common site of metastasis, when it occurs, is the lung; metastases infrequently involve the lymph nodes. Standard therapy for DFSP is local excision. Since a wide margin of at least 3 cm is recommended, many patients may experience disfigurement or impairment in function. Recurrence...
