Human Herpesvirus 8 Load and Progression of AIDS-related Kaposi Sarcoma Lesions

Cancer Lett. 2008 May 18;263(2):182-188, MM Nsubuga, RJ Biggar, S Combs, V Marshall, G Mbisa, F Kambugu, M Mehta, B Biryahwaho, CS Rabkin, D Whitby, SM Mbulaiteye

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Abstract

Abstract

Human herpesvirus 8 (HHV8) is necessary for Kaposi sarcoma (KS) to develop, but whether peripheral blood viral load is a marker of KS burden (total number of KS lesions), KS progression (the rate of eruption of new KS lesions), or both is unclear. We investigated these relationships in persons with AIDS.  Newly diagnosed patients with AIDS-related KS attending Mulago Hospital, in Kampala, Uganda, were assessed for KS burden and progression by questionnaire and medical examination. Venous blood samples...

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