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Highly Active Antiretroviral Therapy and the Incidence of Non–AIDS-Defining Cancers in People With HIV Infection
The Link Between HAART and Non–AIDS-Defining Cancers
T Powles, D Robinson, J Stebbing, J Shamash, M Nelson, B Gazzard, S Mandelia, H Møller, M Bower
20081129
2008 Dec 29
J Clin Oncol
Highly Active Antiretroviral Therapy and the Incidence of Non–AIDS-Defining Cancers in People With HIV Infection
J Clin Oncol. 2008 Dec 29;[Epub ahead of print], T Powles, D Robinson, J Stebbing, J Shamash, M Nelson, B Gazzard, S Mandelia, H Møller, M Bower
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Abstract
SUMMARY
OncologySTAT Editorial Team
Patients who are infected with human immunodeficiency virus (HIV) have an increased risk for developing certain non–AIDS-defining cancers (NADCs), which appear to be associated with immunosuppression. Viral oncogenes are the suspected source of pathogenesis for the AIDS-defining cancers (ie, Kaposi’s sarcoma and non-Hodgkin’s lymphoma [NHL] and for some, but not all, NADCs. It is unclear why the incidence of certain NADCs is increased in immunocompromised patients. Although most published evidence...
