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High Incidence of Arterial Thrombosis in Young Patients Treated for Multiple Myeloma: Results of a Prospective Cohort Study
Arterial Thrombosis in Young Patients Treated for Multiple Myeloma
EJ Libourel, P Sonneveld, B van der Holt, MPM de Maat, FWG Leebeek
20100615
2010 Jul 15
Blood
High Incidence of Arterial Thrombosis in Young Patients Treated for Multiple Myeloma: Results of a Prospective Cohort Study
Blood. 2010 Jul 15;116(1):22-26, EJ Libourel, P Sonneveld, B van der Holt, MPM de Maat, FWG Leebeek
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Abstract
Abstract
This prospective study evaluated the risk of arterial thrombosis in 195 consecutive patients aged 18-65 years with newly diagnosed multiple myeloma (MM). All patients were treated with 3 cycles of VAD (vincristine, doxorubicin and dexamethasone) or TAD (thalidomide-AD) or PAD (bortezomib-AD) in national trials, followed by high dose melphalan and autologous stem cell transplantation. Over a period of 522 patient-years 11 of the 195 patients (5.6%) developed arterial thrombosis. The highest incidence...
